Engineering Programmable DNA Particles and Capsules Using Catechol-Functionalized DNA Block Copolymers

CJ Kim; F Ercole; E Goudeli; SK Bhangu; J Chen; M Faria; JF Quinn; F Caruso

Journal article

Engineering Programmable DNA Particles and Capsules Using Catechol-Functionalized DNA Block Copolymers

CJ Kim, F Ercole, E Goudeli, SK Bhangu, J Chen, M Faria, JF Quinn, F Caruso

Chemistry of Materials | AMER CHEMICAL SOC | Published : 2022

DOI: 10.1021/acs.chemmater.2c01586

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Abstract

DNA block copolymer (DBC) assemblies have attracted attention because of their tunable properties (e.g., programmability, high biocompatibility, efficient cellular uptake, and stability against enzymatic degradation); however, controlling the size of DNA block copolymer assemblies and preparing well-defined DNA-functionalized particle systems are challenging. Herein, we report the preparation of DBC-based particles and capsules with different sizes (i.e., from approximately 0.15 to 3.2 μm) and a narrow size distribution (i.e., polydispersity index <0.2) through the assembly of catechol-functionalized DBC, DNA-b-poly(methyl methacrylate-co-2-methacryloylethyl dihydrocaffeate, with metal ions ..

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University of Melbourne Researchers

Eirini Goudeli Author

Roop Bhangu Author

Jingqu Chen Author

Matt Faria Author

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Grants

Awarded by University of Melbourne

Funding Acknowledgements

This research was funded by the Australian Research Council (ARC) through the Discovery Project (DP200100713) scheme. F.C. acknowledges the award of a National Health and Medical Research Council Senior Principal Research Fellowship (GNT1135806) . J.F.Q. acknowledges the receipt of a Future Fellowship (FT170100144) from the ARC. This work was performed in part at the Materials Characterization and Fabrication Platform (MCFP) at The University of Melbourne and the Victorian Node of the Australian National Fabrication Facility (ANFF) . This research was supported by The University of Melbourne's Research Computing Services and the Petascale Campus Initiative. We thank Dr. Christina Cortez -Jugo, Dr. Francesca Cavalieri, Dr. Robert De Rose, and Denzil Furtado for helpful discussions.